Advanced Science
06 July 2023
DEX-Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T-Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy
Ruinan Jia1,†, Tao Sun2,†, Xin Zhao1, Guosheng Li1,2, Yuan Xia1, Ying Zhou1, Wˇei Li1, Wei Li1, Daoxin Ma1,2, Jingjing Ye1,2,*, Min Ji1,* and Chunyan Ji1,2,*
1 Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012 P.R. China
2 Shandong Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, 250012 P.R. China
† R.J. and T.S. contributed equally to this study.
10.1002/advs.202370125
In article number 2205854, Jingjing Ye, Min Ji, Chunyan Ji, and co-workers observed aberrant adipogenesis in the bone marrow of chemotherapy-treated T-cell acute lymphoblastic leukemia (T-ALL) patients, and the differentiated-adipocytes attract and support residual T-ALL cells. Last, an SREBF1 inhibitor demonstrates superior improvement on therapeutic effect of dexamethason by reducing adipogenesis and provides a feasible strategy to solve the dilemma of recurrence.
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